Porter Hotel Building, 1898
This Hotel Stratton sign is very hard to see in its entirety. You can see "HOTEL STRATTON" okay but below that in large letters is "ROOMS." To the left of that is a finger-pointing image but you have to be on about a 2-foot square bit of sidewalk to see that. It's also adjacent to, and partially covered by, the Coca-Cola sign from several posts ago.
I'm guessing this was painted before the three-story Trivet Towers was built in 1902, otherwise there's no way it could have been seen effectively. Peek around billboards and trees to see it at SW 3rd and Ash.